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Phytochemistry 55, 481504

355,356 The abundant lipids and membrane-bound proteins on the surface of exosomes provide binding sites for targeting ligands, such as peptides, antibodies, and aptamers

The N-terminal hexanoyl cap and specific hydrophobic amino acid sequence (Tyr-Ile-Ahx) were engineered specifically to increase lipophilicity and metabolic stability, allowing Dihexa to cross cell membranes and the blood-brain barrier intact in preclinical models