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Neurons, astrocytes, and oligodendrocytes all express it, and IGF-1 signaling has documented roles in neurogenesis, synaptogenesis, myelination, and neuronal survival
Furthermore, the CTLA-4 gene placed on 2q33 is known as the second most important immunoregulatory gene in autoimmune thyroid disease
Modulation of ultraviolet response pathways: Melanin serves as a natural photoprotective pigment by absorbing and dissipating ultraviolet radiation
(Watanabe and Sato, 1998)
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