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Implications Amylin is centrally implicated in metabolic disease: dysregulated synthesis, impaired pro-IAPP processing and aggregation of amylin into islet amyloid are associated with -cell dysfunction and the progressive loss of -cell mass in type 2 diabetes (T2D)

These drugs slow down the emptying of the stomach, which helps increase satiety and reduce overall food intake

Do not split, crush, or chew the tablet, as this destroys the protective formulation and the absorption enhancer

Most people who have a gastric bypass or a sleeve gastrectomy lose most of their weight within the first 6 months which stabilises around 12 to 18 months later

Lopaschuk GD, Verma S (2020) Mechanisms of cardiovascular benefits of sodium glucose co-transporter 2 (SGLT2) inhibitors: a state-of-the-art review