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In humans, insulin-like growth factor type 1 (IGF-1) and several of its binding proteins are positively associated with acquisition of PBM and the maintenance of bone mineral density (BMD) (911) and low IGF-1 levels have been found to be a risk factor for osteoporosis and fracture risk (3,1219)
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Relative expression levels of mGIPR and mGLP1R were scored on a scale of 0-4 based on ACD scoring criteria, where level 2 indicates 4-9 dots/cell, no or very few dot clusters
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Peptides may eventually become part of that toolkit, but human trials need to come first
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