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[3][16][17] In conditions such as obesity, type 2 diabetes, and aging, NNMT is overexpressed in adipose tissue and skeletal muscle, where it depletes cellular pools of NAD+ and SAM
A clinical study using DSIP in chronic insomnia patients reported significant improvements in sleep onset latency and subjective sleep quality at doses as low as 25 nmol (approximately 90 mcg) (Schneider-Helmert & Schoenenberger, 1983
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doi:10.1210/jc.2017-01155
Similar results have been obtained in rats [2,3]
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