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H4R plays a key protective antibacterial role in innate immune signaling As both adaptive T-cell and innate immune responses likely contribute to inflammation in colitis, we wondered what the effect of losing both adaptive immunity and this novel innate immune H4R-mediated pathway would be on mice undergoing experimental colitis
McCord et al., 2020
Inflammation remains for too long
It does one thing exceptionally well
KPV's anti-inflammatory effects gradually diminish over 1-2 weeks after cessation, so underlying inflammatory conditions may slowly return without the active NF-kB suppression
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