semaglutide 1mg injection Hims & Hers stock falls 25% as FDA curtails compounded GLP-1s Wegovy (semaglutide) Weight Loss Injection

Glucagon-like peptide 1 receptor (GLP1R) is a GPCR drug target found in the pancreas and on neurons of the brain

By mimicking the action of the GLP-1 hormone, semaglutide helps to reduce appetite and increase feelings of fullness and satiety after meals

Increases in resting heart rate are a recognised class effect of incretin-based therapies and have been reported with GLP-1 receptor agonists more broadly, as reflected in the Summary of Product Characteristics (SmPC) for licensed agents such as semaglutide (Wegovy) and liraglutide (Saxenda)

Lipid profiles improve too

But some people would be expected to stop taking the drug due to side effects researchers estimated this to be about 20%