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Psychiatry 32 , 117127 (2024)
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Each metabolic transformation (the conversion of one molecule to another) that makes up human metabolism is catalyzed by a unique enzyme which is coded for by a unique gene
There are more than 19 billion overweight adults and 650 million obese ones globally, according to the World Health Organization ( Maintaining long-term weight control is challenging due to the metabolism variation ( Several anti-obesity drugs, such as orlistat, naltrexone-bupropion, phentermine-topiramate and liraglutide, have provided sufficient evidence on weight loss for adults ( Semaglutide, a novel, long-acting GLP-1 RAs, shows significant performance on weight reduction in several clinical trials ( Here, in this study, we conducted a comprehensive systematic review and meta-analysis to provide an up-to-date evaluation of semaglutide on efficacy and safety of weight loss, especially under the different administration situations, such as the weekly dosages, administration frequencies, trial durations, baseline obesity classifications and whether accompanied with lifestyle interventions
