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The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]

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Supplementary material The Supplementary Material for this article can be found online at: Supplementary material The 1 H NMR of the active ingredients extracted and isolated from Fibraurea recisa Pierre can be seen in Supplementary Figures 15

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