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FIGURE 2 3.1 Brain insulin resistance Insulin resistance in the brain perpetuates neuroinflammation, tau hyperphosphorylation, and amyloid pathology in AD and is therefore a driver of neurodegenerative disease (Steen et al., 2005)
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For instance, GLP-1 and Exendin-4 can act on the gonadal axis, involving the hypothalamic kiss-1 system, to influence reproductive efficiency in female rats [51]
10.1016/j.bbalip.2016.07.014 3 AgmonE.SolonJ.BassereauP.StockwellB
Gisondi P
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