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Meanwhile, ELA may bind to the cellular components with negative charges after entry into the microbial cells, thereby affecting the normal metabolic function

Krane RJ

The dose-response data show a weight effect that flattens toward the top of the range alongside dose-dependent gastrointestinal adverse events, which is consistent with a tolerability-driven choice but that reading is an inference drawn here, not a documented rationale, and Novo Nordisk has published no dose-selection statement

Schmitz O, Russell-Jones D, Shaw J, et al