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[24] Conventional iron uptake pathways, such as those using the transferrin receptor 1 (TfR1), often prove insufficient to meet these elevated iron demands in cancer cells

This means insulin release occurs only when blood glucose levels are elevated, reducing the risk of hypoglycemia compared to other antidiabetic agents, though this risk increases when used with insulin or sulfonylureas

Methods This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations.17 Inclusion criteria The protocol of this study was based on the Patients of interest, Intervention to be studied, Comparison of intervention, and Outcome of interest (PICO) methodology

Vascular endothelial growth factor (VEGF) and its receptors, as key factors promoting angiogenesis, are upregulated under hypoxic conditions

Antioxidant Protection Once in the bloodstream, glutathione acts as a powerful antioxidant, neutralizing harmful free radicals and reactive oxygen species (ROS) that can damage cells and DNA