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Our studies show that GLP-1 receptor agonists strongly activate the hypothalamic pituitary adrenal (HPA) axis the system that produces stress hormones such as cortisol in humans and corticosterone in preclinical models

even lower doses (0.05 mg/kg) were effective in alcohol-preferring strains (18)

The injectable version of has already got the go-ahead from the FDA to treat Bardet-Biedl syndrome, a rare genetic disorder that affects many body systems, causing symptoms including obesity

For example, the cerebellum exhibits relatively high glutathione activity, which contributes to its enhanced resistance to oxidative damage

Research indicates that GLP-1RAs exert protective effects on the liver through various mechanisms, including anti-inflammatory actions, regulation of hepatic lipid metabolism, and enhancement of hepatocyte survival