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By inhibiting NNMT activity, 5-Amino-1MQ has been investigated for its potential to alter intracellular nicotinamide metabolism, increase nicotinamide adenine dinucleotide (NAD) availability, and improve mitochondrial energy utilization
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This becomes particularly important in parts of the body, such as the spinal cord, where there are a lot of nerve cells
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This microvascular dysfunction is heavily implicated in the hallmark symptoms of dysautonomia and ME/CFS, such as orthostatic intolerance (feeling faint or dizzy upon standing) and post-exertional malaise (PEM)
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