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However, in these cases, the excess glutamate comes from within the brain itself, not from the diet. There is no evidence of brain damage in humans resulting from dietary glutamate. Bottom line: Glutamate in the brain is synthesized in the brain

These initial experiences do not predict long-term outcomes

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Kunin and Gallily, 1983)

Use caution in patients with a history of anaphylaxis or angioedema with another glucagon-like peptide-1 (GLP-1) receptor agonist (RA) because it is unknown whether such patients will be predisposed to anaphylaxis