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Enhanced biomechanical strength of healing ligaments in animal studies suggests potential for reduced re-injury risk and faster return to activity

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Treatment consists of replacement of kidney tubular losses, symptomatic management of systemic complications, and specific therapy directed at the basic defect, i.e., lysosomal cystine accumulation

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Cardiac-specific elision of Fth1 (encoding ferritin heavy chain) causes iron dysregulation and increased oxidative stress in the heart, leading to increased sensitivity to ferroptosis induced by iron overload [76]

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