Melanotan-2: The Shotgun Approach MT-2 hits the same MC1R receptor but also activates MC3R, MC4R, and MC5R : MC1R Melanin production (tanning) MC3R Energy homeostasis, cardiovascular function MC4R Sexual arousal, appetite regulation, erectile function MC5R Exocrine gland function, sebaceous secretion This non-selective binding is why MT-2 causes the "side effects" that many users actually seek out particularly the libido and appetite suppression effects
Mounjaro vs Wegovy: Understanding the Medications Before looking at the switching process, let's recap the basics GLP-1 receptor agonist GIP receptor agonist Slows gastric emptying GLP-1 receptor agonist Regulates blood sugar Reduces appetite Chronic weight management (Licensed specifically for weight loss) Starting dose: 2.5mg Maximum: 15mg weekly Starting dose: 0.25mg Maximum: 2.4mg weekly May be more effective at higher doses NICE approved Newer medication with promising results Well-established efficacy NICE approved for weight management Diarrhoea Decreased appetite Vomiting Constipation Vomiting Diarrhoea Constipation Abdominal pain Higher monthly cost Limited NHS availability Private prescription required More affordable option Available on NHS in some areas Private options available Multiple Endocrine Neoplasia syndrome type 2 Severe gastroparesis Pregnancy and breastfeeding Multiple Endocrine Neoplasia syndrome type 2 Severe gastroparesis Pregnancy and breastfeeding Important: This comparison is for educational purposes only
Evening dosing on an empty stomach lines the peptide pulse up with your natural nighttime GH release
You can read that here.
Liu W, Ge T, Leng Y, Pan Z, Fan J, Yang W, Cui R (2017) The role of neural plasticity in depression: from hippocampus to prefrontal cortex
