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In preclinical models, co-administration of bimagrumab or dual myostatin/activin A inhibitors with GLP-1R agonists preserves or increases muscle mass while enhancing fat loss, resulting in improved body composition and metabolic outcomes compared with GLP-1R agonist monotherapy [176]

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Lange described the REIMAGINE results as promising, pointing to the pairing of a novel amylin analogue with semaglutides established effects on both glucose control and weight