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The first phase is the direct stimulation of sensory nerve endings by formalin, which causes acute pain as an inflammatory response, and the second phase causes persistent pain by central sensitization
This innovation is particularly noteworthy because it aims to revolutionise the patient experience by eliminating the discomfort and phobia associated with needles
However, some protocols may require multiple pens
Depending on the situation, doctors may also order tests such as folate, iron studies, methylmalonic acid, homocysteine, or thyroid tests
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