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10.1021/acs.nanolett.1c00895 Nano Lett

While some ROS act as signaling molecules under physiological conditions, excess production disrupts redox homeostasis and damages proteins, lipids, and DNA ( Mitochondria are the primary source of intracellular ROS, primarily generated during electron transfer through complexes I-IV of the electron transport chain (ETC) ( 2 donate electrons that reduce molecular oxygen to water, driving ATP synthesis at complex V (ATP synthase)

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