None had a placebo control group
254 Although few genetic factors are known for ALS, multiple susceptibility variants exist in the major histocompatibility complex (MHC), especially in the human leukocyte antigen (HLA)
Furthermore, limited diagnostic capabilities, difficulty in identifying eligible patients, and variability in disease progression collectively contribute to low enrollment rates, prolonged study timelines, and compromised data integrity in rare disease trials, ultimately resulting in higher failure rates compared to non-rare disease trials 5,6
Liver histology Liver tissue was fixed overnight in 10% formaldehyde, transferred to 70% ethanol for 48 h and then processed into paraffin blocks
They also mentioned better mood and sleep quality