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Theres a lot of horrible methodologies, and there are also just the variables that go down in methodology

Bibcode:2016PNAS..113E.884W

Some possible explanations for the contradictory finding include the small sample sizes of the studies, the lack of multicenter or large-sample size studies to verify the reproducibility and generalizability of the results, and the effect of discontinuation conditions and depression itself on the validation of the conclusions of the Chengdu-based study (Figure 1)

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