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The transcriptome analysis revealed that overexpression of VaPAT1 ( Phytochrome A signal transduction 1 ) and VaIDD3 (INDETERMINATE-DOMAIN 3) enhanced cold tolerance in plants by modulating expression of lipoxygenase 3 ( LOX3 ), gene involved in JA biosynthesis [126] (Fig

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Still, strong safety data is a different claim than proven efficacy, and AOD-9604 currently has the latter unresolved while the former is well established

doi: 10.1016/j.toxlet.2016.12.017 102 JungTBaderNGruneT