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107 In prostate cancer, anti-androgen therapies such as enzalutamide induce the histone reader ZMYND8, which cooperates with FOXM1 to activate neuroendocrine transcriptional programs (e.g., ASCL1), facilitating transdifferentiation into neuroendocrine prostate cancer (NEPC)

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80 Studies of pantethine consumption have demonstrated significant reductions in total cholesterol and LDL cholesterol (up to 13.5%), triglycerides, and elevation of HDL cholesterol in people with high cholesterol 81,82 and diabetic individuals 83 when taken at 9001,200 mg/day, although significant effects on triglycerides have been observed at dosages as low as 600 mg/day

This article explores the scientific evidence, clarifies when B12 supplementation might be associated with anxiety-like symptoms, and provides guidance on safe management aligned with UK clinical practice and NICE recommendations

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