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Among them, retatrutide has shown significant clinical advantages in phase II clinical trials, reducing the weight of obese patients by up to 24.2% in 48 weeks and lowering the HbA1c of type 2 diabetes patients by 2.2% in 36 weeks ( 3.3.2 Regulation of hepatic lipid metabolism Triple receptor agonists exhibit promising synergistic effects on hepatic lipid metabolism, a central pathological feature in MASLD

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Hydration becomes even more important with these medications because: They slow gastric emptying, potentially worsening dehydration Side effects like nausea improve with proper hydration Consider setting timed reminders or carrying a reusable water bottle throughout the day