To view digital features for this article go to Introduction Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue that is the first and, thus far, only GLP-1 receptor agonist (GLP-1RA) to be formulated as a once-daily oral tablet for people with type 2 diabetes (T2D) [1,2,3,4]
Electrolyte replacement becomes important if diarrhea is significant
A separate study from Mass General Brigham found that women who discontinued GLP-1 medications before or early in pregnancy gained an average of 7.2 pounds more during pregnancy and experienced higher rates of gestational diabetes, hypertensive disorders, and preterm birth
While the specific impact on GLP-1 receptor agonist absorption has not been extensively studied, proper rotation practices help maintain consistent drug delivery and reduce the risk of injection site complications
Between 2012 and 2014, regulatory authorities approved phentermine/topiramate extended-release, liraglutide (3 mg/day), and naltrexone/bupropion extended-release, which achieved sustained weight loss (12)