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found that estrogen causes an increase in GCL activity in human breast cells in vitro [5]
doi:10.1152/ajpendo.00201.2006 (source) Ionescu M, Frohman LA
It provides a gentler increase than jumping straight to 15mg, and for some researchers, it is enough to restart progress without the full side effect burden of the maximum dose
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Published Phase 2 and Phase 3 trials for both molecules enrol as monotherapy (with or without background T2D therapy such as metformin or insulin)
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