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Increased levels of ER36 in breast cancer tissues were associated with reduction in responsiveness to tamoxifen in ER66 + breast cancer patients 29

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This article should not be interpreted as clinical guidance for microdosing practices but should instead serve as a resource for clinicians who may consider microdosing tirzepatide- MDP for patients who would benefit from this alternative dosing strategy Microdosing tirzepatide is not endorsed by the manufacturer or approved by any regulatory agency While microdosing is a reasonable approach to individualizing care the lack of supporting data should give pause to inexperienced users, considering the possible medical and legal implications and liability for dosing errors or adverse events experienced by patients