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Thus, inhibition of the proximal half of the TCAC inhibits the fatty-acid oxidation pathway
They suppress or dysregulate the innate immune response, impair the adaptive immune response, and damage the mucosal barriers of the gut and respiratory tract
While side effects are rare, some individuals may experience minor discomfort at the injection site, swelling, or allergic reactions
The extended-SCLC cohort included 26 patients that progressed after no more than 1 prior line of platinum-based chemotherapy and ICIs, and who received SG 10 mg/kg on days 1 and 8 of a 21-day cycle
Ma et al., 2019a
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