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Avoid heavy exercise and excessive sun exposure in the 24 hours before a session

stepwise or concerted mechanism

Biol Mass Spectrom

But stress, sun exposure, aging, and modern life drain it faster than most people realize

Patients with insufficient glutathione stores (e.g., alcoholics and acquired immunodeficiency syndrome patients) and patients with induced cytochrome P-450 enzymatic activity (e.g., alcoholics and those taking concurrent anticonvulsant or antituberculous medications) may be at greater risk for developing acetaminophen-induced hepatotoxicity following overdose (as opposed to therapeutic dosing described earlier)