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What Is Included in the Medical Weight Loss Program
Unlike earlier-generation weight-management agents, retatrutide is a triple receptor agonist , meaning it simultaneously activates three distinct hormonal receptors: GLP-1 (glucagon-like peptide-1) receptor promotes insulin secretion, reduces appetite, and slows gastric emptying [9] [10] GIP (glucose-dependent insulinotropic polypeptide) receptor enhances insulin release and may improve fat metabolism [12] [13] Glucagon receptor increases energy expenditure and may reduce hepatic steatosis, as suggested by imaging data (MRI-PDFF) from Phase 2 trials, though this effect requires confirmation in larger studies [2] [5] This triple-agonist mechanism distinguishes retatrutide from agents such as semaglutide (GLP-1 only) or tirzepatide (GLP-1/GIP dual agonist), and is thought to produce more pronounced reductions in body weight and improvements in metabolic parameters
Dose-dependent reductions in A1C and body weight at higher doses in people with type 2 diabetes have been demonstrated in the phase 2 evaluation of oral semaglutide, suggesting that oral semaglutide at higher doses may provide a more individualized treatment option in people with type 2 diabetes who need additional glycemic control and/or additional weight reduction, explained Sue Pedersen, MD, FRCPC, Specialist in Endocrinology and Metabolism at C-ENDO Diabetes & Endocrinology Clinic, Calgary, Canada
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