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Combined Approaches (Neelakantan et al., 2022): NNMT inhibition with reduced-calorie diet produced dramatic adiposity reduction in DIO mice, normalizing metabolic parameters and establishing a distinct gut microbiome

It has shown a strong safety profile in animal research and good tolerance in human research subjects, but large-scale human clinical trials are still needed

It achieves this by stimulating the formation of new blood vessels, a process known as angiogenesis, which is crucial for delivering nutrients and oxygen to healing tissues

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