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It follows that long-acting GLP-1RAs have a longer half-life and show prolongation of the glucose-lowering effects [3]

GLP-1 stands for glucagon-like peptide-1, which is a natural hormone released in our body after eating

Also, rapid desensitization of surface receptors that are prevented from entering the endocytic pathway may be less relevant with agonists such as exendin-phe1, for which -arrestin recruitment is markedly reduced

In the context of their expanding use beyond glycemic control (particularly in obesity management) establishing this kind of evidence-based reassurance is essential

This underscores the urgent need for novel therapeutic strategies to mitigate residual cardiovascular risk in this high-risk population