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Both drugs are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or MEN 2, and neither should be used during pregnancy

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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver

Irl Hirsch, a professor at the University of Washington School of Medicine, said he had recently seen a patient with type 1 diabetes who was very frustrated with her diabetes care