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Patients who implemented substantial lifestyle changes during treatmentincluding regular physical activity, dietary modifications, and behavioral strategiestend to regain less weight than those who relied primarily on the medication's appetite-suppressing effects

Covariates for the updated model for s.c./i.v./oral administration included the known covariate relationships for the s.c./i.v

GLP-1s, first approved for type 2 diabetes in 2005, lower blood glucose, help avoid fatty liver disease, and help with obesity-related problems such as knee pain, sleep apnea, and gastroesophageal reflux