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Zepbound should not be used with other GLP-1 receptor agonists, other tirzepatide products, or in combination with other prescription, over-the-counter, or herbal weight loss products, as these combinations have not been studied

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MT-1s MC1R-preferential activity makes it the primary research tool for studying MC1R biology in pigmentation, photoprotection, and skin immunology without the confounding central melanocortin receptor activation that limits the interpretability of studies using less selective melanocortin agonists

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This means injections should be administered only by qualified clinicians, and patients need to be fully informed