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110 - 116 Copyright Copyright The Authors 2008 Over the last few years, increasing evidence has shown that hyperhomocysteinaemia is an independent risk factor for the development of CVD ( Reference Wyss and Schulze 1 , Reference Harbor-Gonalves, Vaz and Bezzi 2 ) and may be associated with neurodegenerative disease ( Reference Obeid and Herrmann 3 , Reference Bender, Koch and Elstner 4 ) , diabetes ( Reference Wijekoon, Brosnan and Brosnan 5 ) and end-stage renal dysfunction ( Reference Taes, Delanghe and De Vriese 6 , Reference Taes, Delanghe and De Bacquer 7 )