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A 2.5 mg track has short direct data and real-world support for stable maintainers, but continuing tirzepatide has much stronger evidence than stopping. At week 112, stepping down to 5 mg preserved 16.6% weight loss versus 21.9% on the top dose and 9.9% on placebo

The gap between the gene expression research (which suggests systemic biological effects) and the actual human evidence (which is limited to topical skin endpoints) is substantial

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