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Distribution studies indicate PT-141 crosses the blood-brain barrier effectively, consistent with its centrally-mediated mechanism of action
Lower starting doses or dosage adjustments may be necessary in elderly patients to minimize the risk of side effects
doi: 10.1093/nar/gkae973 Summary Keywords macrophages, neutrophil, fatty acid, gouty arthritis, monosodium urate, fatty acid metabolism Citation Zhao X, Sun Y, Yang L, Sun H, Zhang X, Sun H, Yan G and Wang X (2025) Fatty acid metabolism in gouty arthritis: mechanisms to therapeutic targeting
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However, while their antioxidant effects have been extensively tested in terms of food stability, studies investigating their impact on human health remain limited
