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The expression vectors for the FIX albumin fusion variants were kindly provided by Alessio Branchini (University of Ferrara, Italy) 9

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Transactivation of NRF2 in KO livers was further supported by constitutive induction of NRF2 target genes, including Gclc , metallothionein I ( Mt1 ) and heme-oxgenase 1 ( Hmox1) (Fig

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