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Semaglutide 2.4mg (Wegovy) is contraindicated in pregnancy, while other GLP-1 receptor agonists are generally not recommended

Tirzepatide: Mounjaro (diabetes), Zepbound (weight management) Semaglutide: Ozempic (diabetes), Wegovy (weight management), Rybelsus (oral diabetes) Same active ingredients, different approved indications and brand names Cost remains a significant consideration for Canadian patients

Physiologically, it can bind to GLP-1 receptor on pancreatic beta cells through endocrine, activate adenylate cyclase, increase intracellular cAMP levels, promote glycolysis and ATP production, and enhance glucose-stimulated insulin secretion

Since the insulinotropic but not the gastric-inhibitory action of GIP prevailed at physiological concentrations [30,31,32], the peptide was later renamed glucose-dependent insulinotropic polypeptide

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