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2.3 Dysregulation and failure of endogenous antioxidant defense mechanisms Under physiological conditions, the myocardium maintains redox homeostasis through a robust endogenous antioxidant defense system, comprising enzymatic components like SOD, Catalase (CAT), and Glutathione Peroxidases (GPxs), as well as non-enzymatic antioxidants such as glutathione (GSH) and thioredoxin (Kumar et al., 2022)

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The ATP6AP1 KO showed an increased lysosomal pH of 4.8, which was unaltered upon ACT treatment

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