This should be balanced against potential negative effects on body composition, bone density and frailty fractures [90, 91]
Aside from that, several other factors keep compounded semaglutide and semaglutide distinct from one another
While medication alone wont solve this global health crisis, GLP-1 therapies can help millions overcome obesity and reduce its associated harms. The WHO did qualify its recommendations, saying endorsement is conditional due to limited data on their long-term efficacy and safety, maintenance and discontinuation, their current costs, inadequate health-system preparedness, and potential equity implications. The drugs should not be used by pregnant women, and should be paired with evidence-based interventions like healthy diets and physical activity, the guidelines also stress
While the amount of weight lost is a primary factor, age, skin elasticity, and the speed of weight loss also play a role
Moreover, the growing coverage of GLP-1 drugs by Medicare is also expected to help meet demand