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(1999), TB-500 was found to enhance wound healing in a rat model
External and iatrogenic causes: Excessive supplementation: High-dose oral supplements or frequent intramuscular injections (hydroxocobalamin or cyanocobalamin) can elevate serum levels, though this rarely causes problems
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When dietary choline intake is insufficient (common in calorie-restricted diets), hepatic fat export slows, leading to non-alcoholic fatty liver accumulation even during active weight loss
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