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The authors concluded that GHK and GHK-Cu increased epidermal cell stemness and keratinocyte proliferation, also increasing p63 and integrin expression [ 48 , 49 ]

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1 EC is mainly categorized into two histological subtypes, squamous-cell carcinoma (SCC) and adenocarcinoma (AC), which differ substantially in their geographical distribution, etiology, and pathogenesis

By contrast, the chronic phase is characterized by persistent cognitive decline, worsening psychiatric symptoms, and progressive motor dysfunction as neuroinflammation and neuronal loss become more pronounced (McCann et al., 2008)

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