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The anti-fibrotic effects of GLP-1RAs may arise from their ability to improve metabolic control, reduce body weight, and directly affect HSCs
a.A.KandilH.et al (2021)
In practice this means the clinician evaluating you must be licensed in California, must gather enough information to make a defensible clinical judgment, and is held to the same standard as if you were sitting in an exam room
Many of these side effects are manageable and often reduce in severity over time
While not approved for prediabetes, GLP-1 receptor agonists may be considered in individuals at high risk of developing type 2 diabetes, especially if lifestyle interventions are insufficient
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