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Regarding lipids metabolism, multiple studies have confirmed its close correlation with epilepsy: for example, sphingosine 1-phosphate can protect mitochondrial structure and function to alleviate neuronal hyperexcitability and damage in patients with DRE (143)
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The third body is in vivo rodent work, largely on muscle, bone, gut and neural tissue, some of it using the LR3 variant specifically because its altered clearance and reduced binding-protein capture change tissue exposure relative to native protein
Sigman M, Glass S, Campagnone J, Pryor JL
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