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A recent meta-analysis reported comparing each strategy of combo therapy with the up-titration of basal insulin, showing no significant difference between the two approaches in HbA1c change, target HbA1c achievement rate, hypoglycemic risk, and body weight change (23)

For example, in clinical trials, nausea was reported in up to 44% of patients taking Wegovy at the maintenance dose

It reduces the burden of frequent injections on research models, minimizes stress, and helps maintain steady-state concentrations of the peptide, leading to more consistent research outcomes

Willmot, M., Leonardi-Bee, J

Advances in Nutrition: An International Review Journal