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Lower DSIP levels have been correlated with depressive states, suggesting its involvement in hypothalamic-pituitary-adrenal (HPA) axis modulation ( 11 )
There are no published studies examining interactions between neuropathy peptides and gabapentinoids
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Picomolar to nanomolar activity suggests high receptor affinity and potent biological signalling, which is encouraging for topical delivery where only a fraction of applied compound reaches the follicle
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