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In parallel, obesity has started to be viewed as a chronic metabolic disease with possible severe consequences, no longer just the stigmatised condition resulting from a lack of willpower, as sometimes portrayed in the past

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Although epithelial-based and macrophage-based barriers operate later, MCC acts earlier and impacts all formulations, making it the primary barrier to effective inhaled drug delivery 120,121,122

Its carefully balanced formulation ensures compatibility with most common peptide compounds without compromising structural integrity or experimental consistency

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